Cyclic acetals as cleavable linkers for affinity capture
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چکیده
منابع مشابه
Cyclic acetals as cleavable linkers for affinity capture.
Labeling proteins with biotin is a widely used method to identify target proteins due to biotin's strong binding affinity for streptavidin. Combined with alkyne-azide cycloaddition, which enables the coupling of probes to targeted proteins, biotin tags linked to an alkyne or azide have become a powerful tool for purification and analysis of proteins in proteomics. However, biotin requires harsh...
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Desorption/ionization on silicon mass spectrometry (DIOSMS) uses porous silicon (pSi) to generate gas-phase ions of small (< 3000 Da) molecules without a matrix by using standard MALDI (matrix-assisted laser desorption/ionization) instrumentation. The unique laser desorption/ionization surface properties of DIOSMS allow for the simultaneous detection of a broad range of small molecules as their...
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A series of cyclic acetals were investigated with regard to their ability to function as coinitiators in free-radical photopolymerization induced by camphorquinone (CQ). Among these cyclic acetals, the reactivity of 2-hexyl-1,3-benzodioxole (HBDO) was the highest, according to the quantum yield of CQ. However, the most efficient coinitiator was l,3-benzodioxolane, which has a reactivity signifi...
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This review article focuses on concepts that incorporate safety-catch and multiply cleavable linkers in solid-phase synthesis. Discussed are specific applications of such linkers in the synthesis of peptides, peptide mimetics, and “small” organic molecules, as well as their limitations for particular chemistries and reaction conditions. © 1999 John Wiley & Sons, Inc. Biopoly 47: 353–363, 1998
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2015
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c5ob01056j